Research Paper Volume 16, Issue 20 pp 13132—13144
OSBPL2 inhibition leads to apoptosis of cochlea hair cells in age-related hearing loss by inhibiting the AKT/FOXG1 signaling pathway
Figure 7. OSBPL2 downregulation and inactivation of AKT/FOXG1 signaling pathways in the cochleae of aged C57BL/6 mice. (A) ABR thresholds of C57BL/6 mice from Young (n=6) and Old (n=6) groups in response to tone pips of 8, 12, 16, 20, 24, 28, and 32 kHz. (B) Western blotting for expression levels of OSBPL2 and proteins related to AKT and FOXG1 signaling pathways in the cochleae of young and old C57BL/6 mice. (C, D) Association between OSBPL2 and p-AKT or FOXG1 expression in the cochleae of aged C57BL/6 mice. (E) Association between p-AKT and FOXG1 expression in the cochleae of aged C57BL/6 mice. * P<0.05; ** P<0.01.