OSBPL2 inhibition leads to apoptosis of cochlea hair cells in age-related hearing loss by inhibiting the AKT/FOXG1 signaling pathway

Meina Li-Yang; Chao Ma; Xiaoye Wang; Jianqiang You

doi:doi:10.18632/aging.206138

← Back

Research Paper Volume 16, Issue 20 pp 13132—13144

OSBPL2 inhibition leads to apoptosis of cochlea hair cells in age-related hearing loss by inhibiting the AKT/FOXG1 signaling pathway

Figure 6. OSBPL2 deletion promotes H₂O₂-induced HEI-OC1 cell apoptosis by downregulating FOXG1 expression. (A) The cell viability of HEI-OC1 cells from H₂O₂, H₂O₂+MK2206, H₂O₂+MK2206+FOXG1-OE, H₂O₂+sh-OSBPL2, H₂O₂+sh-OSBPL2+SC79, and H₂O₂+sh-OSBPL2+SC79+sh-FOXG1 groups. (B) The cell apoptosis of HEI-OC1 cells from each group. (C) Bax and Bcl-2 protein levels in HEI-OC1 cells from each group. All in vitro experiments were performed in triplicate (n = 3). * P<0.05; ** P<0.01.