Research Paper Volume 16, Issue 20 pp 12977—13011
Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells
Figure 8. Replicatively senescing cells reduce the levels of LBR, Lamin B1, and the associated protein complexes. (A) Quantitations of IF in situ analyses of the levels of LBR and Lamin B1 in the nuclei of early (young, Y) and late passage (old, O) normal human dermal fibroblasts. (B, C) Quantitations of the indicated PLA analyses in the same cells as in (A). All panels represent two independent experiments. Crossbars in graphs are distribution means.