Research Paper Advance Articles
Use of the senolytics dasatinib and quercetin for prevention of pelvic organ prolapse in a mouse animal model
Figure 4. Impact of serial dasatinib and quercetin (D+Q) injections on elastin content in the vaginal tissue of wild type (WT) and Fibulin-5 knockout (Fbln-5-/-) mice at 20 weeks of life. Representative tissue sections from 20-week-old WT and Fbln-5-/- mice (A). Top panels correspond to WT and Fbln-5-/- mice in the control group and the bottom panels correspond to WT and Fbln-5-/- mice in the D+Q group. Quantification of vaginal tissue elastin content at 10, 12 and 20 weeks of life in WT control, WT treatment, Fbln-5-/- control and Fbln-5-/- treatment groups (B). Results are expressed as raw mean percent of total tissue ± SEM. 20x magnification.