Research Paper Volume 16, Issue 19 pp 12685—12696
Use of the senolytics dasatinib and quercetin for prevention of pelvic organ prolapse in a mouse animal model
Figure 3. Impact of serial dasatinib and quercetin (D+Q) injections on p53 expression in the vaginal tissue of wild type (WT) and Fibulin-5 knockout (Fbln-5-/-) mice at 20 weeks of life. Representative tissue sections from WT control, WT treatment, Fbln-5-/- control and Fbln-5-/- treatment mice. Top panels demonstrate differences in p53 expression between groups. Bottom panels display corresponding DAPI staining to label cellular nuclei for anatomical reference. Epi=epithelium, Musc=muscularis. 20x magnification.