Research Paper Volume 16, Issue 19 pp 12850—12865
USP4 promotes PTC progression by stabilizing LDHA and activating the MAPK and AKT signaling pathway
Figure 7. Schematic model of the function and mechanism of USP4 in thyroid cancers. USP4 promotes PTC progression by enhancing LDHA protein stability through deubiquitination. Consequently, this process activates both the MAPK and AKT signaling pathways.