Research Paper Volume 16, Issue 17 pp 12379—12391
Cigarette smoke-induced exosomal miR-221-3p facilitates M1 macrophage polarization via the STAT3 pathway in chronic obstructive pulmonary disease
Figure 6. Induction of M1 macrophage differentiation by exosomal miR-221-3p from cigarette smoke (CS)-exposed cells. (A, B) Numbers of CD11b+ monocytes in response to cigarette smoke-induced exosomes miR-221-3p treated with epithelial cells, as assessed using flow cytometry. (C, D) Numbers of CD163+ macrophages in response to cigarette smoke-induced exosomes miR-221-3p, as assessed using flow cytometry. Data are shown as the mean ± SEM (n = 3–5 replicates). *P < 0.05; **P < 0.01; *** P < 0.001; ****P < 0.0001.