Research Paper Volume 16, Issue 17 pp 12379—12391
Cigarette smoke-induced exosomal miR-221-3p facilitates M1 macrophage polarization via the STAT3 pathway in chronic obstructive pulmonary disease
Figure 2. Immune microenvironment in COPD induced by cigarette smoke. (A, B) Mass cytometry was utilized to examine alterations in immune cell composition in the lung tissue of the COPD C57BL/6 mouse model (n = 5 replicates). (C, D) Moreover, flow cytometry analysis revealed a significant rise in immune cells in the lung tissue of COPD mice. Data are shown as the mean ± SEM (n = 3-5 replicates). *P < 0.05; **P < 0.01; *** P < 0.001; ****P < 0.0001.