Research Paper Volume 16, Issue 17 pp 12379—12391
Cigarette smoke-induced exosomal miR-221-3p facilitates M1 macrophage polarization via the STAT3 pathway in chronic obstructive pulmonary disease
Figure 1. Clarification of relevant functions in COPD using GEO data. (A, B) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) enrichment analysis revealed that immune pathways (immune system processes; immune response) and vesicle pathways (extracellular exosomes; endosomal system) are associated with COPD. (C, D) Gene Set Enrichment Analysis (GSEA) demonstrated a significant correlation between COPD and antigen presentation as well as immune response pathways.