Research Paper Volume 16, Issue 17 pp 12335—12345
Treatment of tumor-associated macrophages with PD-1 monoclonal antibodies affects vascular generation in cervical cancer via the PD-1/IRE1α/SHP2/HIF1α signaling pathway
Figure 6. PD-1 monoclonal antibodies in tumor-associated macrophages inhibit the migration and angiogenesis of cervical cancer cells by affecting the PD-1/IRE1α/SHP2/HIF1α signaling pathway, thereby suppressing the progression of cervical cancer. (A) Sindilizumab inhibits M2 polarisation in tumour-associated macrophages by affecting the SHP2/STAT3/STAT6/HIF1α signalling pathway. (B) Sindilizumab inhibits migration and angiogenesis of cervical cancer cells by affecting the PD-1/IRE1α/SHP2/HIF1α signalling pathway.