Research Paper Volume 16, Issue 17 pp 12277—12292
CIB2 mediates acquired gefitinib resistance by inducing ZEB1 expression and epithelial-mesenchymal transition
Figure 3. CIB2 acted as an oncogene in lung cancer development. (A, B) Cell proliferation abilities of CIB2 knockout or overexpression were measured using the CCK8 assay. (C, D) Cell migration and invasion activities of indicated cells were analyzed using the Transwell assay. (E, F) Indicated cells were used to test colony formation activities with soft agar assay. Data were statistically analyzed using Student’s t-test and values were shown as mean ± SD of three independent experiments. **indicated significant difference at p < 0.01, ***indicated significant difference at p < 0.001.