miR-424-5p suppresses the proliferation and immigration of oral squamous cell carcinoma via down-regulation of KDR

Junqing Zhang; Zhangui Tang; Guanghui Bao

doi:doi:10.18632/aging.206083

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Withdrawal Notice

This paper was originally published in Aging Advance Online Publications on August 26, 2024.

In compliance with Aging's withdrawal policy, the paper was withdrawn in its entirety. It will not appear in Aging internal or any external indexes or archives.

WITHDRAWN: miR-424-5p suppresses the proliferation and immigration of oral squamous cell carcinoma via down-regulation of KDR

Figure 3. miR-424-5p-induced downregulation of KDR. (A) A volcano map of the differentially expressed miRNAs and mRNAs (n = 19349) identified between the normal samples and the OSCC samples based on data from the GEO dataset. (B) miR-424-5p expression data from the TCGA-OSCC dataset. (C) Survival curves based on miR-424-5p expression data and tumor grade from the TCGA-OSCC dataset. (D) Expression of miR-424-5p in the HOK cell line and OSCC cell lines (n = 4 in each group). (E) TargetScan predicts the binding site between miR-424-5p and promoter of KDR. (F) Dual luciferase reporter gene assay showing the targeted binding of miR-424-5p and KDR. ^*P < 0.05 ^**P < 0.01.