Mechanistic study of PD-L1 regulation of metastatic proliferation in non-small cell lung cancer through modulation of IRE1α/XBP-1 signaling pathway in tumor-associated macrophages

Yi Wang; Lei Yang; Zezheng Liang; Ming Liu

doi:doi:10.18632/aging.206082

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Research Paper Volume 16, Issue 16 pp 12063—12072

Mechanistic study of PD-L1 regulation of metastatic proliferation in non-small cell lung cancer through modulation of IRE1α/XBP-1 signaling pathway in tumor-associated macrophages

Figure 1. PD-L1 monoclonal antibodies as well as IRE1α inhibitors have inhibitory effects on NSCLC tumors. (A) Comparison and statistics of tumor volume size in each group. (B) Comparison and statistics of tumor area size in each group. (C) Comparison and statistics of indicator P-IRE1α and XBP-1 in each group. (^*P < 0.05; ^**P < 0.01).