Research Paper Volume 16, Issue 16 pp 12029—12049

Figure 4. Genetic alterations of UBR1 in gastric cancer. (A) Analysis of the frequency of UBR1 mutations across various cancers using the cBioPortal database. (B) Frequency and types of genetic alterations of UBR1 in gastric cancer, including amplifications, deletions, and mutations. (C) Identification and analysis of UBR1 mutation sites, mutated amino acids, and their association with post-translational modifications, along with the overall frequency of these somatic mutations. (D) Mutation landscape of the top 15 genes with the highest frequency of UBR1 mutations in gastric cancer. (E) 4D structure of the UBR1 protein retrieved from the HPA database. (F, G) Correlation of UBR1 with Tumor Mutation Burden (TMB) and Microsatellite Instability (MSI) in malignancies, presented in radar charts.