Research Paper Volume 16, Issue 16 pp 12029—12049
UBR1 is a prognostic biomarker and therapeutic target associated with immune cell infiltration in gastric cancer
Figure 3. Prognostic role of UBR1 in gastric cancer. (A) Overall survival (OS) curves for patients expressing UBR1 were plotted using the Kaplan-Meier Plotter database, revealing a significant association (p < 0.05). (B) The progression-free interval survival curve also indicated a significant correlation with UBR1 expression (p < 0.05). (C) The disease-specific survival curve demonstrated a significant link (p < 0.05). Further validation was performed using OS data from GEO datasets:(D) GSE15459 (p < 0.01), (E) GSE51105 (p < 0.05), (F) GSE62254 (p < 0.0001). (G) subgroup analyses revealed significant OS differences based on UBR1 expression in: Female patients (p < 0.05). (H) Patients with GC who underwent successful surgery (p < 0.05). (I) GC patients treated with chemotherapy (p < 0.05).