Research Paper Volume 16, Issue 16 pp 11970—11993

Figure 4. In ischemic stroke, the effect estimates 6 DNA methylation-based phenotypes and telomere length. (A) Examination of the association between an increase in ischemic stroke exposure and the risk of DNA histone modifications-estimated phenotypes and Telomere length, utilising Inverse variance weighed, MR Egger, Simple mode, Weighted mode and Weighted median estimates. (B) Scatter plots showing distinct SNP effects and approximations from various MR methods to investigate the effect of stroke caused by ischemic stroke on the acceleration of DNA methylation PhenoAge. (C) funnel Diagram of Ischemic Stroke on accelerated DNA methylation PhenoAge. (D) Leave-one-out regression diagrams for Ischemic Stroke and accelerated DNA methylation PhenoAge. (E) Scatter plots illustrating distinct SNP effects and estimates from various MR techniques depicting the influence of Ischemic Stroke on Telomere duration. (F) Ischemic Stroke funnel plots on Telomere length. (G) Leave-one-out evaluation plots for the effect of Ischemic Stroke on Telomere length.