Research Paper Volume 16, Issue 17 pp 12239—12251

Figure 6. MTA2 depletion inhibits osteosarcoma metastasis in vivo. (A) shLuc- and shMTA2-143B cells (1 × 10⁶ /0.1mL) were injected into the tail vein of C.B17-SCID mice for ten weeks; mice were then sacrificed and the lung tissues removed, shLuc and shMTA2 143B lung tumor excised from C.B17-SCID mice. (B) Number of nodules in lung tumors and (C) body weight among shLuc and shMTA2 mice. (D) H&E staining for tissue morphology and IHC staining for Ki-67 and MTA2 in shLuc and shMTA2 mice. Scale bar: 100 μm. (E) Depiction of the role and biological function of the control of uPA expression by MTA2 in human osteosarcoma metastasis.