Research Paper Volume 16, Issue 17 pp 12239—12251
MTA2 knockdown suppresses human osteosarcoma metastasis by inhibiting uPA expression
Figure 5. ERK1/2 is involved in MTA2-mediated regulation of human osteosarcoma cell migration and invasion. (A) The expression of activated ERK1/2 in shLuc and shMTA2 cells by western blot assay. (B) Transfection of si-Con or si-ERK in shLuc and shMTA2 osteosarcoma cells for 24 h, followed by the western blot and (C) in vitro Boyden chamber migration and invasion assay. ** P < 0.01, compared with shLuc cells; # P < 0.05, compared with shMTA2 cells.