Research Paper Volume 16, Issue 17 pp 12239—12251
MTA2 knockdown suppresses human osteosarcoma metastasis by inhibiting uPA expression
Figure 3. MTA2 depletion inhibits human osteosarcoma metastasis by decreasing uPA expression. (A) shLuc and shMTA2 osteosarcoma cells were extracted, collected, and detected using a human proteinase array. (B, C) The mRNA and protein expression of uPA in both osteosarcoma cell lines by RT-qPCR and western blot assay. (D) Analysis of MTA2 expression between normal and tumor tissues from osteosarcoma patients using the TNMplot database. (E) Correlation analysis between MTA2 and uPA expression in human osteosarcoma tissues using GEPIA software. ** P < 0.01.