Research Paper Volume 16, Issue 16 pp 11926—11938
Caffeic acid derivative MPMCA suppresses osteoclastogenesis and facilitates osteoclast apoptosis: implications for the treatment of bone loss disorders
Figure 8. The graphic illustrates the signaling pathways impacted by MPMCA, leading to the suppression of osteoclast activity. MPMCA hinders the transformation of macrophages into osteoclasts and intensifies the cell apoptosis of mature osteoclasts. MPMCA facilitates the inhibition of MAPKs (ERK, p38 and JNK) and NF-κB signaling pathways.