Research Paper Volume 16, Issue 16 pp 11926—11938

Caffeic acid derivative MPMCA suppresses osteoclastogenesis and facilitates osteoclast apoptosis: implications for the treatment of bone loss disorders

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Figure 6. MPMCA hinders the activation of MAPKs and NF-κB. (A) KEGG pathway database map illustrating the significantly upregulated pathways in the GSE21639 database. (BF) Western blot analysis reveals the phosphorylation of MAPKs and p65 in RAW 264.7 cells following treatment with RANKL and MPMCA at specific time intervals (n = 3). *p < 0.05 vs. RANKL-treated group.