Research Paper Volume 16, Issue 16 pp 11926—11938

Caffeic acid derivative MPMCA suppresses osteoclastogenesis and facilitates osteoclast apoptosis: implications for the treatment of bone loss disorders

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Figure 4. MPMCA induces apoptosis in mature osteoclasts. (A) The RAW 264.7 cells were cultured with RANKL for 5 days, followed by treatment with RANKL and MPMCA for an additional 2 days. (B) TRAP staining was performed on RAW 264.7 cells. (C) Quantitative results derived from TRAP staining in RAW 264.7 cells (n = 3). *p < 0.05 vs. control group. #p < 0.05 vs. RANKL-treated group.