Research Paper Volume 16, Issue 16 pp 11926—11938
Caffeic acid derivative MPMCA suppresses osteoclastogenesis and facilitates osteoclast apoptosis: implications for the treatment of bone loss disorders
Figure 1. MPMCA effectively suppresses the formation of osteoclasts induced by RANKL. (A) Diagram illustrating the structure of MPMCA. (B) MTT assays were performed to evaluate the viability of RAW 264.7 cells after being treated with MPMCA for 24 hours (n = 3). (C) Schematic illustrating the inhibitory effect of MPMCA on the process of osteoclast development. (D, E) TRAP staining was conducted to quantify the number of osteoclasts in RAW 264.7 cells after 7 days of treatment with RANKL and MPMCA (n = 3). *p < 0.05 vs. control group. #p < 0.05 vs. RANKL-treated group.