Research Paper Volume 16, Issue 16 pp 11904—11916

Figure 6. miR-432-5p attenuates ADR-induced toxicity via RTN3. (A–C) The mimic of miR-432-5p, si-RTN3, or OE-RTN3 were transfected into cardiomyocyte, and si-RTN3 and miR-432-5p mimic attenuate ADR-induced toxicity by cell viability (A), ROS (B), IL-1β (C) and LDH (D) level with the protection that was abolished by OE-RTN3; (E) Western blot analysis indicates RTN3 was knockdown or upregulated and accompanied by changing of LC3B, cleaved-caspase 3, Beclin 1, and CHOP in cardiomyocyte. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.