Research Paper Volume 16, Issue 17 pp 12225—12238
Melatonin downregulates angiogenesis and lymphangiogenesis by regulating tumor-associated macrophages via NLRP3 inflammasomes in lung adenocarcinoma
Figure 6. Melatonin inhibited the expression of the NLRP3 pathway in tumor tissues and peripheral blood of mice. (A, B) mRNA expression levels of NLRP3 pathway components (NLRP3 and IL-1β) in tumor tissues evaluated by RT-PCR. (C–F) Protein expression levels of NLRP3 pathway components (NLRP3, pro-L-1β and IL-1β) in tumor tissues assessed by western blotting. (G) Expression levels of IL-1β in peripheral blood of mice analyzed by ELISA. *p < 0.05, **p < 0.01, vs. control group. Data provided as mean ± SD (n = 3).