Research Paper Volume 16, Issue 17 pp 12225—12238
Melatonin downregulates angiogenesis and lymphangiogenesis by regulating tumor-associated macrophages via NLRP3 inflammasomes in lung adenocarcinoma
Figure 5. Effects of melatonin and NLRP3 pathway modulation on tumor growth in mice. (A) Subcutaneous tumor volume in mice monitored over time in different treatment groups. (B) Tumor volume after 30 days among different groups compared to the control group. (C, D) In vivo fluorescence imaging and quantification of mean fluorescence intensity in subcutaneous tumors from different groups. *p < 0.05, **p < 0.01, vs. control group. Data provided as mean ± SD (n = 3).