Research Paper Volume 16, Issue 17 pp 12225—12238
Melatonin downregulates angiogenesis and lymphangiogenesis by regulating tumor-associated macrophages via NLRP3 inflammasomes in lung adenocarcinoma
Figure 2. Co-culturing THP-1 macrophages with A549 promoted TME angiogenesis and lymphangiogenesis. (A) The VEGF-A, VEGF-B, VEGF-C, CXCL8, CXCL5 protein expressions, as detected by ELISA. (B, C) Branch point quantification. Typical phase-contrast images revealing tube formation. *p < 0.05, **p < 0.01. Data provided as mean ± SD (n = 3).