Research Paper Volume 16, Issue 16 pp 11857—11876
Circ_0006476 modulates macrophage apoptosis through the miR-3074-5p/DLL4 axis: implications for Notch signalling pathway regulation in cardiovascular disease
Figure 8. Schematic representation of the effects of nicotine on THP-1 macrophages. Nicotine exposure upregulates circ_0006476 expression, leading to competitive binding with miR-3074-5p and subsequent activation of DLL4. Activated DLL4 triggers apoptosis through the Notch signalling pathway.