Figure 4. (A) Venn diagram showed the intersection of blood metabolites that are causally involved in HER+ and HER-breast cancers. (B) Forest plots showed the causal associations between blood metabolites (Gamma-glutamyl glutamate levels and X-12849 levels) and HER+ breast cancer by using different methods. (C) Forest plots showed the causal associations between blood metabolites (Gamma-glutamyl glutamate levels and X-12849 levels) and HER- breast cancer by using different methods. Abbreviations: SNP: single nucleotide polymorphism; OR: odds ratio; CI: confidence interval.