Research Paper Advance Articles
Angiotensin-(1-7) relieves behavioral defects and α-synuclein expression through NEAT1/miR-153-3p axis in Parkinson’s disease
Figure 2. Overexpression of miR-153-3p reduces the level of α-syn and relieves the apoptosis in the hα-syn(A53T) overexpressed dopaminergic neurons. (H) Cell cytotoxicity of primary dopaminergic neurons in each group was tested by LDH assay (n = 3). (I) The levels of Bcl2, Bax and cleaved caspase-3 in every group were observed by Western blot (n = 3). (J) Quantitative evaluation of Bcl2 level. (K) Quantitative evaluation of Bax level. (L) Quantitative evaluation of Cleaved caspase-3 level. Data are shown as the mean ± SD. *P<0.05 versus the hα-syn(A53T) + NC mimic group; **P<0.01 versus the NC mimic, hα-syn(A53T) or hα-syn(A53T) + NC mimic group; ***P<0.001 versus the NC mimic or hα-syn(A53T) + NC mimic group; #P<0.05, ##P<0.01 and ###P<0.001 versus the hα-syn(A53T) + NC inhibitor group. ####P<0.0001 versus the NC inhibitor group.