Research Paper Advance Articles
Angiotensin-(1-7) relieves behavioral defects and α-synuclein expression through NEAT1/miR-153-3p axis in Parkinson’s disease
Figure 1. Ang-(1-7) takes a protective part in the hα-syn overexpressed PD model of mice. (A) The Ang-(1-7) levels within SN in different groups were examined using enzyme-linked immunosorbent assay (n = 6). (B) The MasR levels within SN in different groups were assessed by Western blot (n = 6). (C) Quantitative evaluation of MasR level. (D) The latency time in the Rotarod test were recorded (n = 21). (E) The movement time in the open field test were shown (n = 21). (F) Cells were labeled by anti-TH (red) and anti-α-syn (green) antibodies, nuclei were counterstained with DAPI (blue). The immunofluorescence was surveyed using a fluorescent microscopy. Scale bar, 100 μm (n = 6). Data are shown as the mean ± SD. ****P<0.0001 versus the Control group; #P<0.05, ##P<0.01 and ####P<0.0001 versus the hα-syn(A53T) group.