Research Paper Volume 16, Issue 15 pp 11568—11576
Circular RNA circMRPS35 represses malignant progression in osteosarcoma cells via targeting miR-105-5p/FOXO1
Figure 4. CircMRPS35 regulates viability and apoptosis of osteosarcoma cells by targeting miR-105-5p/FOXO1 axis. (A–D) The MG63 and MNNG/HOS cells were treated with circMRPS35 overexpressing plasmid, or co-treated with circMRPS35 overexpressing plasmid and miR-105-5p mimic or FOXO1 siRNA. (A, B) The cell viability was analyzed by CCK-8 assay. (C, D) The cell apoptosis was measured by flow cytometry analysis. **P < 0.01.