Research Paper Volume 16, Issue 13 pp 10724—10748

Co-analysis of methylation platforms for signatures of biological aging in the domestic dog reveals previously unexplored confounding factors

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Figure 3. Tree representation of the capture sequencing, mammalian methylation array and RRBS methylation datasets. (AC) The edges of each tree are colored with a gradient according to the age of each sample. The smaller trees at the top right corner of each panel correspond to genetic distance where age is also represented as a color gradient. The color of the innermost ring of the bigger and smaller trees corresponds to FCI clade, the middle ring corresponds to sex, and the length and color of the outermost bars to weight. (D) Venn diagram depicting the number of intersecting loci between the three studies. This also includes probes from the human EPIC commercial array [37], a methylation array platform commonly used in human studies, which align to the dog genome.