Research Paper Volume 16, Issue 13 pp 11103—11116
HOXC4 promotes proliferation of pancreatic cancer cells by increasing LDHA-mediated glycolysis
Figure 5. LDHA is a target of HOXC4 in PC. (A) Motif of HOXC4. (B) HOXC4 can bind to the promoter of LDHA. (C) Chip-qPCR was used to verify the binding. (D) HOXC4 increased the luciferase activity of LDHA in PC cells, while mutation of the associating element in the promoter of LDHA abolished the effect of the HOXC4 on luciferase activity. (E, F) The mRNA and protein expression of LDHA was regulated by HOXC4. (G) Co-expression between HOXC4 and LDHA in PC tissues. *P < 0.05; **P < 0.01.