Research Paper Volume 16, Issue 13 pp 11103—11116
HOXC4 promotes proliferation of pancreatic cancer cells by increasing LDHA-mediated glycolysis
Figure 4. HOXC4 regulates glycolysis in PC cells. (A) DEGs between PC tissues with high and low HOXC4 expression. (B) Reactome analysis of the top200 up-regulated genes in PC with high HOXC4 expression. (C) GSEA for the expression of HOXC4. (D) Extracellular acidification rate in SW1990 and PANC-1 cells while HOXC4 was overexpressed or inhibited. (E, F) Glucose uptake and lactate production in SW1990 and PANC-1 cells while HOXC4 was overexpressed or inhibited. *P < 0.05, **P < 0.01.