Research Paper Volume 16, Issue 13 pp 11090—11102
LIMK1 promotes the development of cervical cancer by up-regulating the ROS/Src-FAK/cofilin signaling pathway
Figure 7. LIMK1 regulated the expression of p-FAK and p-Cofilin-1 proteins by regulating ROS and p-Src. (A) Effect of 5.0 μM Saracatinib or 5 mM NAC-treated SiHa cells on the expression of LIMK1, NOX2, p-Src, p-FAK, and p-Cofilin-1 proteins in cervical cancer cells and histograms of statistical analyses by Western blotting. (B) Plot of the results of the cell scratch experiment and statistics of cell scratch spacing. (C) Graphs of the results of Transwell experiments and statistics on the number of cells migrating and invading. (D) CCK8 experimental results are plotted. **P<0.01 indicated statistically significant differences; nsP>0.05 indicates that the difference is not statistically significant.