Research Paper Volume 16, Issue 13 pp 11072—11089
AK7-deficiency reversal inhibits ccRCC progression and boosts anti-PD1 immunotherapy sensitivity
Figure 6. Overexpression of AK7 inhibits RCC growth and enhances anti-PD1 efficacy. (A) Schematic diagram of establishment of mouse subcutaneous tumor model in each group. (B) Three lentiviruses were designed to overexpress AK7 expression in RENCA cell lines, and their overexpression efficiency was verified by qRT-PCR. (C) Images of subcutaneous tumors in each group. (D, E) Analysis of subcutaneous tumors in the respective groups. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.