Research Paper Volume 16, Issue 13 pp 10997—11017

Figure 9. The disulfidptosis score is associated with response to therapy in multiple cancer types. (A) Kaplan–Meier curves of OS between low and high groups stratified by the disulfidptosis score in the melanoma immunotherapy dataset. (B) The response rate to immunotherapy in low and high groups stratified by disulfidptosis score in the melanoma dataset. (C) Kaplan-Meier curves for OS in late-stage non-squamous non-small cell lung cancer combined targeted therapy (bevacizumab + erlotinib) comparing low and high groups stratified by the disulfidptosis score. (D) The response rate to combined targeted therapy (bevacizumab + erlotinib) in late-stage non-squamous non-small cell lung cancer in low and high groups stratified by disulfidptosis score. (E, F) Bubble plot showing the relationship between mRNA expression of genes related to disulfidptosis in pan-cancer and GDSC or CTRP drug sensitivity (top 30). The color from blue to red represents the correlation between mRNA expression and IC₅₀. Blue bubbles represent negative correlations; red bubbles represent positive correlations; the deeper the color, the higher the correlation. A positive correlation means that a gene with a high level of expression is resistant to the drug, and vice versa. The bubble size positively correlates with the FDR significance.