Research Paper Volume 16, Issue 13 pp 10997—11017

Figure 1. The difference in disulfidptosis genes expression in pan-cancer and survival analyses. (A) Heatmap showing the difference in disulfidptosis gene expression in 31 cancer types from the TCGA database compared with normal paracancerous tissues from the TCGA and GTEx databases. The red and blue indicate high or low expression (p<0.05), respectively. The white indicates no difference in expression (p≥0.05). (B) Heatmap of the correlation between disulfidptosis genes across cancers. Darker colors represent stronger correlations. (C) Univariate Cox regression analysis was performed on the disulfidptosis gene in pan-cancer, and the p-value and HR value were extracted and displayed using a heat map (R pheatmap package). The gray indicates p>0.05; for p<0.05, the red indicates HR>1, and the blue indicates HR<1 (R survival and survival packages). (D) Kaplan-Meier survival analysis was performed for the disulfidptosis genes in pan-cancer, and a heatmap was performed for display (pheatmap package). p> 0.05 is gray; for p<0.05, the red represents poor prognosis with high expression, and blue represents good prognosis with high expression (R survival and survival packages). (E) Genetic alterations of the disulfidptosis gene in pan-cancer.