Figure 4. Identification of key disulfidptosis-related genes in DN. (A) Intersection analysis identifying 21 critical genes related to disulfidptosis in DN through single-cell analysis, differential expression, and WGCNA. (B) Protein interaction network analysis highlighting MAGI2 as a central factor in gene-gene interactions. (C, D) Functional enrichment analysis of the 21 key genes, showing significant association with receptor internalization and MAPK signaling pathway.