Research Paper Advance Articles
Unfolding the mysteries of heterogeneity from a high-resolution perspective: integration analysis of single-cell multi-omics and spatial omics revealed functionally heterogeneous cancer cells in ccRCC
Figure 5. Clinical values of functionally heterogeneous cancer cells in ccRCC. (A) Kaplan-Meier survival analysis of TCGA ccRCC cohort based on infiltration levels calculated by CIBERSORTx analysis (up) and ssGSEA score calculated by characteristic genes (down) of functionally heterogeneous cancer cells. The grouped metrics are based on the optimal cutoff value, and the numbers in parentheses represent the ccRCC sample size. (B) Univariate and multivariate Cox analyses showing the associations between clinical indicators (age, gender, and stage), infiltration levels and ssGSEA scores with patients’ survival outcomes (the prognostic value of functionally heterogeneous cancer cells of the three meta programs).