Research Paper Volume 16, Issue 13 pp 10943—10971
Unfolding the mysteries of heterogeneity from a high-resolution perspective: integration analysis of single-cell multi-omics and spatial omics revealed functionally heterogeneous cancer cells in ccRCC
Figure 4. Spatial location information and signature gene characteristics of functionally heterogeneous cancer cells in ccRCC. (A) Spatial location information of functionally heterogeneous cancer cells revealed by stRNA-seq, illustrating the distribution of cancer cells in tumor lesions. (B) Signature gene characteristics of functionally heterogeneous cancer cells in scRNA-seq data, showing the expression levels of signature genes of different meta programs. (C) Spatial expression patterns for signature gene characteristics of functionally heterogeneous cancer cells in stRNA-seq data. (D) Signature gene characteristics of functionally heterogeneous cancer cells validated by clinical samples of ccRCC using immunofluorescence.