Luteolin targets the AGE-RAGE signaling to mitigate inflammation and ferroptosis in chronic atrophic gastritis

Nailin Zhang; Pingping Chen; Xiaoyan Liang; Jianhui Sun; Qiquan Liu; Shengjiang Guan; Qiao Wang

doi:doi:10.18632/aging.205969

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Research Paper Volume 16, Issue 13 pp 10918—10930

Luteolin targets the AGE-RAGE signaling to mitigate inflammation and ferroptosis in chronic atrophic gastritis

Figure 5. Luteolin inhibits ferroptosis in rat gastric tissue. (A) Changes in the levels of Fe²⁺ and MDA in gastric tissues of luteolin-treated rats. (B) Changes in the mRNA expression of FIH1, COX2, ACSL4, GPX4, and NOX1 were detected using qPCR. (C) Western blot analysis of the protein expression levels of FIH1, COX2, ACSL4, GPX4, and NOX1.