Research Paper Volume 16, Issue 13 pp 10882—10904
Disorder of neuroplasticity aggravates cognitive impairment via neuroinflammation associated with intestinal flora dysbiosis in chronic heart failure
Figure 1. The cardiac function and hemal physiological and biological indices in CHF rats. (A) Animal experiment timeline. (B) Representative electrocardiograms at 24 hours before and after surgery. (C–E) Representative M mode echocardiograms of Sham and CHF rats (C) and quantifications of left ventricular ejection fraction (LVEF) (D), left ventricular fraction shortening (LVFS) (E). (F–I) Quantifications of cardiac hemodynamic parameters, including left ventricular systolic pressure (LVSP) (F), left ventricular end-diastolic pressure (LVEDP) (G), +dp/dtmax (H), −dp/dtmax (I). (J–N) The BNP (J), NT-proBNP (K), cTnT (L), sST2 (M) and Ang II (N) levels in serum were measured by ELISA. Data are presented as the Mean ± SEM; *P < 0.05, and **P < 0.01 vs. Sham; n = 8.