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Research Paper Volume 16, Issue 13 pp 10749—10764

Cathepsin L induces cellular senescence by upregulating CUX1 and p16INK4a

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Figure 1. Correlated expression of CTSL, CUX1 and p16INK4a in human ECs and VSMCs. (A, B) Western blots and qPCR analysis showing upregulation of CTSL, CUX1 and p16INK4a in late passage (p10) versus early passage (p5) human ECs. (C, D) Western blots and qPCR analysis confirming upregulation of CTSL, CUX1 and p16INK4a in late passage (p15) versus early passage (p8) human VSMCs. Data for Western blots represent three biologically independent samples (n = 3). Data for qPCR represent a combination of three (n = 3) biologically independent experiments.