Research Paper Volume 16, Issue 13 pp 10832—10840
Long non-coding RNA HOTTIP promotes renal cell carcinoma progression through the regulation of the miR-506 pathway
Figure 4. The oncogenic functions of HOTTIP are partially mediated through the negative regulation of miR-506. (A) In 786-O cells, RIP confirmed the interaction between lncRNA-HOTTIP and miRNA-506; (B) miRNA-506 can bind specifically to HOTTIP 3 ‘UTR; (C) TCGA database of tumor and paracancerous tissue miR-506 expression; (D) Survival curves of patients with different miR506 expression; (E) The invasion capacity of si-HOTTIP+si-miR-506 cells was enhanced by MTT compared with si-HOTTIP; (F) The proliferation capacity of si-HOTTIP+si-miR-506 cells was enhanced by MTT compared with si-HOTTIP.