Research Paper Advance Articles
Long non-coding RNA HOTTIP promotes renal cell carcinoma progression through the regulation of the miR-506 pathway
Figure 2. Over-expression of lncRNA-HOTTIP increases the proliferation, invasion, and migration of RCC. (A) The proliferation capacity of Caki-1-HOTTIP cells was enhanced by MTT compared with Caki-1-pCDH; (B, C) The proliferation capacity of Caki-1-HOTTIP cells was enhanced compared with that of Caki-1-pCDH cells by plate cloning assay; (D, E) The apoptosis of Caki-1-HOTTIP cells was decreased compared with Caki-1-HOTTIP cells by flow cytometry assay. (F) Hoechst apoptosis assay showed that the apoptosis of Caki-1-HOTTIP cells was weaker than that of Caki-1-pCDH cells. (G) Transwell test showed that the invasion and migration ability of Caki-1-HOTTIP cells were enhanced compared with Caki-1-pCDH cells.