Research Paper Volume 16, Issue 9 pp 8217—8245
Single-cell BCR and transcriptome analysis reveals peripheral immune signatures in patients with thyroid-associated ophthalmopathy
Figure 3. scBCR-seq revealed increased diversity of BCRs in active TAO. (A) The box plot showed the top 10 high-frequency B-cell clonotypes for each sample in active TAO, inactive TAO, and NC group. (B) The distribution of the length of CDR3 amino acid sequence in active TAO, inactive TAO, and NC group. (C) Box plots of Chao1 index for each sample were used to compare the diversity of CDR3of B cells (* p<0.05, ** p<0.01). (D) Box plots of Chao1 index for each sample was used to compare the diversity of CDR3 of Bregs (* p<0.05, ** p<0.01).