Figure 10. RNA-seq validation of significant disulfidptosis modulators. (A) Expression heat map and (B) volcano plot of vertebral bone tissues from patients with OP and controls, assessed by RNA-seq. (C) The disulfidptosis modulator OXSM exhibited increased expression levels in OP samples compared with controls. (D) The disulfidptosis modulator PRDX1 exhibited increased expression levels in OP samples compared with controls. All results are expressed as means ± standard deviations. **P < 0.01, ***P < 0.001.