Research Paper Volume 16, Issue 9 pp 8142—8154
4-hydroxysesamin protects rat with right ventricular failure due to pulmonary hypertension by inhibiting JNK/p38 MAPK signaling
Figure 4. Protective effect of 4-HS on cardiopulmonary function in PH rats. (A) Flowchart of modeling and processing of PH rats. (B) Flowchart of body weight changes of rats in each experimental group from the beginning of PH modeling to the end of modeling, and body weight changes of rats were recorded every 6 days. (C) Detection of changes in systolic pressure of the right ventricle in each experimental group after the end of modeling of PH rats. (D) Detection of changes in Fulton Index in each experimental group. (E) Detection of changes in expression of respiratory rate in each experimental group. (F) Echocardiography measurement of pulmonary artery (PA) function showing normalization of pulmonary acceleration time (PAT). Changes in the expression of respiratory rate. (F) Echocardiography measurement of pulmonary artery (PA) function showing normalization of pulmonary acceleration time (PAT)/pulmonary ejection time (PET) ratio. (G) Detection of changes in EF, FS, LVVs, LVVd, LVIDs, and LVIDd in MCT-induced PH rats after 4-HS treatment.